HuagongsheHuagongshe Chemistry Print Report · For research reference only
Homoallyl bromide → 5-But-3-enyloxy-pyridine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Homoallyl bromide | HCID 21241 | — |
| Reactant | Methyl 5-hydroxypyridine-2-carboxylate | HCID 4715126 | — |
| Reactant | 5-(Cyclopropylmethoxy)pyridine-2-carboxylic acid | HCID 66691895 | — |
| Reactant | 5-But-3-enyloxy-pyridine-2-carboxylic acid methyl ester | HCID 66931510 | — |
| Product | 5-But-3-enyloxy-pyridine-2-carboxylic acid | HCID 66931630 | — |
Reaction Steps
The 5-but-3-enyloxy-pyridine-2-carboxylic acid was prepared in a reaction sequence analogous to that in example 60 for the preparation of the 5-cyclopropylmethoxy-pyridine-2-carboxylic acid: Alkylation of the 5-hydroxy-pyridine-2-carboxylic acid methyl ester with 4-bromo-1-butene and hydrolysis of the 5-but-3-enyloxy-pyridine-2-carboxylic acid methyl ester yielded the 5-but-3-enyloxy-pyridine-2-carboxylic acid as a light yellow solid. Mass (calculated) C10H11NO3 [193.201]; (found) [M+H]+=194.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188079B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-30b616b5ee2441909196d41d2c4b0bf3 |
| Source note | uspto-grants-2012_05 |