4-(4,6-Dimethoxy[1.3.5]triazin-2-yl)-4-methylmorpholinium chloride hydrate → HCID 66931531, compound

HRID 1929516Notes

Reaction equation

HRID 1929516 reaction equation
[Cl:1][C:2]1[C:3]([C:10]([OH:12])=O)=[N:4][CH:5]=[C:6]([C:8]#[N:9])[CH:7]=1.[NH2:13][C:14]1[CH:15]=[CH:16][C:17]([F:51])=[C:18]([C@:20]2([CH3:50])[CH2:25][O:24][CH2:23][C:22]([NH:26][C:27]([C:42]3[CH:47]=[CH:46][C:45]([O:48][CH3:49])=[CH:44][CH:43]=3)([C:34]3[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][CH:35]=3)[C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[N:21]2)[CH:19]=1.O.[Cl-].COC1N=C(OC)N=C([N+]2(C)CCOCC2)N=1>>[CH3:49][O:48][C:45]1[CH:46]=[CH:47][C:42]([C:27]([NH:26][C:22]2[CH2:23][O:24][CH2:25][C@:20]([C:18]3[CH:19]=[C:14]([NH:13][C:10]([C:3]4[C:2]([Cl:1])=[CH:7][C:6]([C:8]#[N:9])=[CH:5][N:4]=4)=[O:12])[CH:15]=[CH:16][C:17]=3[F:51])([CH3:50])[N:21]=2)([C:34]2[CH:35]=[CH:36][C:37]([O:40][CH3:41])=[CH:38][CH:39]=2)[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)=[CH:43][CH:44]=1

Participants

4

Reactant 3

HCID 231494114-(4,6-Dimethoxy[1.3.5]triazin-2-yl)-4-methylmorpholinium chloride hydrateHCID 508531763-Chloro-5-cyanopyridine-2-carboxylic acidHCID 66931535HCID 66931535, compound

Product 1

HCID 66931531HCID 66931531, compoundYield 44%

Procedure

In a manner analogous to that described in example E1 (method E), the reaction of 3-chloro-5-cyano-pyridine-2-carboxylic acid with Building block J, [(R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine, using the 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride hydrate (DMTMM) as the condensating agent, yielded the title compound as a yellow solid (44% of theory). Mass (calculated) C39H33ClFN5O4 [690.160]; (found) [M]+=690.

Sources & evidence

ORD record
ord-3757e02fc4fc4c61980376330e7bf444
Source dataset
uspto-grants-2012_05
Patent number
US08188079B2

Reaction notes

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