3,3,3-Trifluoropropionic acid → HCID 50991223, compound

HRID 1929522Notes

Reaction equation

HRID 1929522 reaction equation
[F:1][C:2]([F:8])([F:7])[CH2:3][C:4](O)=[O:5].[NH2:9][C:10]1[CH:11]=[CH:12][C:13]([F:24])=[C:14]([C:16]2([CH3:23])[CH2:21][O:20][CH2:19][C:18]([NH2:22])=[N:17]2)[CH:15]=1>>[NH2:22][C:18]1[CH2:19][O:20][CH2:21][C:16]([C:14]2[CH:15]=[C:10]([NH:9][C:4](=[O:5])[CH2:3][C:2]([F:8])([F:7])[F:1])[CH:11]=[CH:12][C:13]=2[F:24])([CH3:23])[N:17]=1

Participants

3

Reactant 2

HCID 27779723,3,3-Trifluoropropionic acidHCID 58155285HCID 58155285, compound

Product 1

HCID 50991223HCID 50991223, compound

Procedure

In a manner analogous to that described in example E1 (method E), the condensation of 3,3,3-trifluoro-propionic acid with Building block P, (RS)-5-(5-amino-2-fluoro-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine, yielded the title compound as a yellow oil. Mass (calculated) C14H15F4N3O2 [33.283]; (found) [M+H]+=334.

Sources & evidence

ORD record
ord-0c212d1179474907b48c84f63521178e
Source dataset
uspto-grants-2012_05
Patent number
US08188079B2

Reaction notes

Loading…