Hydrochloric Acid → HCID 68528646, compound

Participants

Reaction Steps

2-thiazolecarboxamidine hydrochloride (Schaefer F. C., Peters G. A., et al.) 2.164 mmol, 2-chloro-4-fluorobenzaldehyde 2.164 mmol, 5,5-dimethyl-1,3-cyclohexanedione 2.164 mmol and sodium acetate 3.2 mmol were reacted in 8 ml of anhydrous ethanol under refluxing for 18 hr, condensed, to which ethyl acetate and water and 1N HCl were added, and separated. The water layer was adjusted with concentrated NaOH solution until pH value to be basic, then ethyl acetate was added and extracted twice. The organic layers were combined, dried over anhydrous sodium sulfate, and separated by column chromatography to obtain a yellow crystal 0.23 g (yield 28%); 1H-NMR (400 MHz, CDCl3-d1) δ 7.95-7.85 (m, 1H, ArH); 7.64-7.47 (m, 1H, ArH); 7, 34-7.24 (m, 1H, ArH); 7.13-7.11 (m, 1H, ArH); 6.11 (s, 1H, CH); 2.70-2.52 (m, 2H, CH2); 2.43-2.26 (m, 2H, CH2); 1.15 (s, 6H, CH3). HREI: 389.0765 (M+).

Provenance & Evidence