Ammonia → HCID 44426225, compound

HRID 1929550Notes

Reaction equation

[CH2:1]1[O:17][C:16]2[C:3](=[CH:4][C:5]3[CH:6]=[C:7]([CH2:20][N:21]4[CH2:28][CH2:27][CH2:26][C@H:22]4[C:23](O)=[O:24])[C:8]4[C:13]([C:14]=3[CH:15]=2)=[CH:12][C:11]([O:18][CH3:19])=[CH:10][CH:9]=4)[O:2]1.N>>[CH2:1]1[O:17][C:16]2[C:3](=[CH:4][C:5]3[CH:6]=[C:7]([CH2:20][N:21]4[CH2:28][CH2:27][CH2:26][C@H:22]4[CH2:23][OH:24])[C:8]4[C:13]([C:14]=3[CH:15]=2)=[CH:12][C:11]([O:18][CH3:19])=[CH:10][CH:9]=4)[O:2]1

Participants

Reactant 2

HCID 222Ammonia

HCID 24205677HCID 24205677, compound

Product 1

HCID 44426225HCID 44426225, compound

Procedure

General procedure f from 31 (95%); white powder; mp 138-139° C.; 1H NMR (400.13 MHz) δ 8.16 (d, J=4 Hz, 1H), 7.88 (s, 1H), 7.80 (d, J=2 Hz, 1H), 7.46 (s, 1H), 7.23 (dd, J=4 Hz, 2 Hz, 1H), 7.14 (s, 1H), 6.07 (s, 2H), 4.03 (s, 2H), 3.94 (s, 3H), 3.70 (d, J=17 Hz, 2H), 3.16 (m, 1H), 2.38 (m, 2H), 2.23 (m, 2H), 1.95 (m, 2H); MS (DCI/NH3) m/e: 366 (M+H)+. Anal. (C22H23O4N) C, H, N.

Sources & evidence

ORD record: ord-e6e9817cc0634055bb3a5205576aea57
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188089B2

Reaction notes

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