Trifluoroacetic acid → [6-Fluoro-3-methyl-4-(piperazine-1-carbonyl)-naphthalen-2-yl]-acetic acid methyl ester trifluoroacetate

Participants

Reaction Steps

A solution of 4-(7-fluoro-3-methoxycarbonylmethyl-2-methyl-naphthalene-1-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester (410 mg, 0.92 mmol) in dichloromethane (10 mL) was treated with trifluoroacetic acid (2.5 mL) at room temperature, and stirred for 4 hours. The resulting mixture was concentrated in vacuo to afford [6-fluoro-3-methyl-4-(piperazine-1-carbonyl)-naphthalen-2-yl]-acetic acid methyl ester trifluoroacetate as a viscous oil which was used in the next step without further purification.

Provenance & Evidence