HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → 3-(2,4-Difluoro-3-methyl-phenyl)-acrylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | 2,4-Difluoro-3-methylbenzaldehyde | HCID 12137489 | — |
| Product | 3-(2,4-Difluoro-3-methyl-phenyl)-acrylic acid | HCID 66733996 | — |
Reaction Steps
According to the previously described general procedure (GP1), Knoevenagel condensation (75° C.; 3h30) between 2,4-difluoro-3-methyl-benzaldehyde (1.560 g; 9.744 mmol) and malonic acid (1.926 g; 18.515 mmol) gave the product 3-(2,4-difluoro-3-methyl-phenyl)-acrylic acid as a pale yellow solid (1.600 g; 83%). LC-MS: tR=0.86 min; [M+H]+: no ionisation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188082B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-df10f7ca732c48608ccd88a057c12193 |
| Source note | uspto-grants-2012_05 |