HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → 3-[2-fluoro-4-(trifluoromethyl)phenyl]prop-2-enoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | 2-Fluoro-4-(trifluoromethyl)benzaldehyde | HCID 522929 | — |
| Product | 3-[2-fluoro-4-(trifluoromethyl)phenyl]prop-2-enoic Acid | HCID 2783402 | — |
Reaction Steps
According to the previously described general procedure (GP1), Knoevenagel condensation (75° C.; 3h20) between 2-fluoro-4-(trifluoromethyl)benzaldehyde (5.000 g; 26.027 mmol) and malonic acid (5.145 g; 49.451 mmol) gave the product 3-(2-fluoro-4-trifluoromethyl-phenyl)-acrylic acid as a colorless solid (5.030 g; 82.5%). LC-MS: tR=0.89 min; [M+H]+: no ionisation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188082B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-88633a0df75f438cb4b4eee17b68db9e |
| Source note | uspto-grants-2012_05 |