HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → 3-[3-fluoro-4-(trifluoromethyl)phenyl]prop-2-enoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | 3-Fluoro-4-(trifluoromethyl)benzaldehyde | HCID 2737537 | — |
| Product | 3-[3-fluoro-4-(trifluoromethyl)phenyl]prop-2-enoic Acid | HCID 2737581 | — |
Reaction Steps
According to the previously described general procedure (GP1), Knoevenagel condensation (75° C.; 3h20) between 3-fluoro-4-trifluoromethyl-benzaldehyde (9.000 g; 46.848 mmol) and malonic acid (9.262 g; 89.012 mmol) gave the product 3-(3-fluoro-4-trifluoromethyl-phenyl)-acrylic acid as a colorless solid (9.520 g; 87%). LC-MS: tR=0.90 min; [M+H]+: no ionisation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188082B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-dfcc2b13d23c4018bb76a150a67fa1f0 |
| Source note | uspto-grants-2012_05 |