HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → 3-Fluoro-4-methylcinnamic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | 3-Fluoro-4-methylbenzaldehyde | HCID 2774574 | — |
| Product | 3-Fluoro-4-methylcinnamic acid | HCID 2774608 | — |
Reaction Steps
According to the previously described general procedure (GP1), Knoevenagel condensation (75° C.; 2h30) between 3-fluoro-4-methyl-benzaldehyde (10.519 g; 76.154 mmol) and malonic acid (15.056 g; 144.694 mmol) gave the product 3-(3-fluoro-4-methyl-phenyl)-acrylic acid as a colorless solid (11.860 g; 86%). LC-MS: tR=0.84 min; [M+H]+: no ionisation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188082B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-920f8b6c2b464ee39e9907fd04ec3c00 |
| Source note | uspto-grants-2012_05 |