HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → 3-(3,4,5-Trifluorophenyl)-2-propenoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | 3,4,5-Trifluorobenzaldehyde | HCID 2776954 | — |
| Product | 3-(3,4,5-Trifluorophenyl)-2-propenoic acid | HCID 2777102 | — |
Reaction Steps
According to the previously described general procedure (GP1), Knoevenagel condensation (75° C.; 3 h) between 3,4,5-trifluorobenzaldehyde (7.000 g; 43.724 mmol) and malonic acid (8.644 g; 83.076 mmol) gave the product 3-(3,4,5-trifluoro-phenyl)-acrylic acid as a yellow solid (8.600 g; 97%). LC-MS: tR=0.91 min.; [M+H]+: no ionisation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188082B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-d69d67d00315486fb0dae7c1a6de6efd |
| Source note | uspto-grants-2012_05 |