HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → HCID 2777277, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | p-(Trifluoromethoxy)benzaldehyde | HCID 69573 | — |
| Product | HCID 2777277 | HCID 2777277 | — |
Reaction Steps
According to the previously described general procedure (GP1), Knoevenagel condensation (75° C.; 6 h) between 4-(trifluoromethoxy)benzaldehyde (10.000 g; 52.598 mmol) and malonic acid (10.399 g; 99.937 mmol) gave the product 3-(4-trifluoromethoxy-phenyl)-acrylic acid as a colorless solid (12.080 g; 99%). LC-MS: tR=0.96 min.; [M+H]+: no ionisation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188082B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-50352396e33c4f56a3d54c87924a58a3 |
| Source note | uspto-grants-2012_05 |