HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → 3-(2,3,5-trifluorophenyl)prop-2-enoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | 2,3,5-Trifluorobenzaldehyde | HCID 2776950 | — |
| Product | 3-(2,3,5-trifluorophenyl)prop-2-enoic Acid | HCID 2777093 | — |
Reaction Steps
According to the previously described general procedure (GP1), Knoevenagel condensation (75° C.; 3h20) between 2,3,5-trifluorobenzaldehyde (9.730 g; 60.777 mmol) and malonic acid (12.016 g; 115.477 mmol) gave the product 3-(2,3,5-trifluoro-phenyl)-acrylic acid as a colorless solid (8.310 g; 68%). LC-MS: tR=0.84 min.; [M+H]+: no ionisation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188082B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-cb6e11ce513b4791b586b7984c837820 |
| Source note | uspto-grants-2012_05 |