HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → 3-(3-Fluoro-4-methoxyphenyl)prop-2-enoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | 3-Fluoro-p-anisaldehyde | HCID 67696 | — |
| Product | 3-(3-Fluoro-4-methoxyphenyl)prop-2-enoic acid | HCID 101843 | — |
Reaction Steps
According to the previously described general procedure (GP1), Knoevenagel condensation (75° C.; 3 h) between 3-fluoro-4-methoxybenzaldehyde (6.080 g; 39.445 mmol) and malonic acid (7.798 g; 74.946 mmol) gave the product 3-(3-fluoro-4-methoxy-phenyl)-acrylic acid as a colorless solid (7.530 g; 97%). LC-MS: tR=0.86 min.; [M+H]+: no ionisation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188082B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-e535183ed8294939a23738b8989ce18e |
| Source note | uspto-grants-2012_05 |