3-(3,4-Difluorophenyl)propanal → HCID 66733731, compound

Participants

Reaction Steps

According to the general procedure (GP10), the microwave-assisted Pictet-Spengler reaction (60 W; 100° C.; 8 bars; 10 min.) between 2-(2-ethyl-4-iodo-imidazol-1-yl)-ethylamine (355.2 mg; 1.340 mmol) and 3-(3,4-difluoro-phenyl)-propionaldehyde (228.7 mg; 1.340 mmol) afforded 8-[2-(3,4-difluoro-phenyl)-ethyl]-3-ethyl-1-iodo-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine which was Boc-protected and finally purified by HPLC.

Provenance & Evidence