HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[4-(Trifluoromethyl)phenyl]propanal → HCID 66733993, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[4-(Trifluoromethyl)phenyl]propanal | HCID 21683807 | — |
| Reactant | 2-(4-Iodo-2-methyl-imidazol-1-yl)-ethylamine | HCID 66733980 | — |
| Product | HCID 66733993 | HCID 66733993 | — |
Reaction Steps
According to the general procedure (GP10), the microwave-assisted Pictet-Spengler reaction (60 W; 110° C.; 8 bars; 10 min.) between 2-(4-iodo-2-methyl-imidazol-1-yl)-ethylamine (373.8 mg; 1.489 mmol) and 3-(4-trifluoromethyl-phenyl)-propionaldehyde (301 mg; 1.489 mmol) afforded 1-iodo-3-methyl-8-[2-(4-trifluoromethyl-phenyl)-ethyl]-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine which was Boc-protected and finally purified by FC (DCM/MeOH=25/1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188082B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-176a9bceabc942468e6e5b31c87f3bda |
| Source note | uspto-grants-2012_05 |