HCID 53434294, compound → HCID 66733869, compound

HRID 1929658Notes

Reaction equation

HRID 1929658 reaction equation
[CH2:1]([C:3]1[N:4]([CH2:9][CH2:10][NH2:11])[CH:5]=[C:6]([I:8])[N:7]=1)[CH3:2].[F:12][C:13]1[CH:14]=[C:15]([CH2:21][CH2:22][CH:23]=O)[CH:16]=[C:17]([F:20])[C:18]=1[F:19]>>[CH2:1]([C:3]1[N:4]2[CH2:9][CH2:10][NH:11][CH:23]([CH2:22][CH2:21][C:15]3[CH:16]=[C:17]([F:20])[C:18]([F:19])=[C:13]([F:12])[CH:14]=3)[C:5]2=[C:6]([I:8])[N:7]=1)[CH3:2]

Participants

3

Reactant 2

HCID 53434294HCID 53434294, compoundHCID 66734063HCID 66734063, compound

Product 1

HCID 66733869HCID 66733869, compound

Procedure

According to the general procedure (GP10), microwave-assisted Pictet-Spengler reaction (60 W; 140° C.; 6.5 bars; 10 min.) between 2-(2-ethyl-4-iodo-imidazol-1-yl)-ethylamine (7.394 mmol) and 3-(3,4,5-trifluoro-phenyl)-propionaldehyde (1.391 g; 7.394 mmol) afforded 3-ethyl-1-iodo-8-[2-(3,4,5-trifluoro-phenyl)-ethyl]-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine. LC-MS: tR=0.74 min.; [M+H]+=435.86 g/mol.

Sources & evidence

ORD record
ord-23d39ff8fb4e40bc894ed7b633785136
Source dataset
uspto-grants-2012_05
Patent number
US08188082B2

Reaction notes

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