HCID 66734063, compound → HCID 66738629, compound

HRID 1929660Notes

Reaction equation

HRID 1929660 reaction equation
[CH2:1]([C:3]1[N:4]([CH2:9][CH2:10][NH2:11])[CH:5]=[C:6]([I:8])[N:7]=1)[CH3:2].[F:12][C:13]1[CH:14]=[C:15]([CH2:22][CH2:23][CH:24]=O)[CH:16]=[C:17]([F:21])[C:18]=1[O:19][CH3:20]>>[F:12][C:13]1[CH:14]=[C:15]([CH2:22][CH2:23][CH:24]2[NH:11][CH2:10][CH2:9][N:4]3[C:3]([CH2:1][CH3:2])=[N:7][C:6]([I:8])=[C:5]23)[CH:16]=[C:17]([F:21])[C:18]=1[O:19][CH3:20]

Participants

3

Reactant 2

HCID 66734063HCID 66734063, compoundHCID 73014074HCID 73014074, compound

Product 1

HCID 66738629HCID 66738629, compound

Procedure

According to the general procedure (GP10), microwave-assisted Pictet-Spengler reaction (60 W; 140° C.; 6.5 bars; 10 min.) between 2-(2-ethyl-4-iodo-imidazol-1-yl)-ethylamine (5.168 mmol) and 3-(3,5-difluoro-4-methoxy-phenyl)-propionaldehyde (1.034 g; 5.168 mmol) afforded 8-[2-(3,5-difluoro-4-methoxy-phenyl)-ethyl]-3-ethyl-1-iodo-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine. LC-MS: tR=0.73 min.; [M+H]+=448.42 g/mol.

Sources & evidence

ORD record
ord-bd2a37858c3b4dd591e0ce6df7d01a20
Source dataset
uspto-grants-2012_05
Patent number
US08188082B2

Reaction notes

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