HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[4-(Trifluoromethyl)phenyl]propanal → HCID 66733882, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[4-(Trifluoromethyl)phenyl]propanal | HCID 21683807 | — |
| Reactant | 2-(4-Iodo-2-propyl-imidazol-1-yl)-ethylamine | HCID 66733617 | — |
| Product | HCID 66733882 | HCID 66733882 | — |
Reaction Steps
According to the general procedure (GP10), microwave-assisted Pictet-Spengler reaction (60 W; 140° C.; 6.5 bars; 10 min.) between 2-(4-iodo-2-propyl-imidazol-1-yl)-ethylamine (9.260 mmol) and 3-(4-trifluoromethyl-phenyl)-propionaldehyde (2.730 g; 13.503 mmol) afforded 1-iodo-3-propyl-8-[2-(4-trifluoromethyl-phenyl)-ethyl]-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine. LC-MS: tR=0.80 min.; [M+H]+=463.88 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188082B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-ce71e1b028d045908eda106dc12415ca |
| Source note | uspto-grants-2012_05 |