HCID 23266324, compound → HCID 66734138, compound

HRID 1929672Notes

Reaction equation

HRID 1929672 reaction equation
[CH2:1]([C:3]1[N:4]([CH2:9][CH2:10][NH2:11])[CH:5]=[C:6]([I:8])[N:7]=1)[CH3:2].[F:12][C:13]([F:25])([F:24])[C:14]1[CH:23]=[CH:22][C:17]([O:18][CH2:19][CH:20]=O)=[CH:16][CH:15]=1>>[CH2:1]([C:3]1[N:4]2[CH2:9][CH2:10][NH:11][CH:20]([CH2:19][O:18][C:17]3[CH:22]=[CH:23][C:14]([C:13]([F:12])([F:24])[F:25])=[CH:15][CH:16]=3)[C:5]2=[C:6]([I:8])[N:7]=1)[CH3:2]

Participants

3

Reactant 2

HCID 23266324HCID 23266324, compoundHCID 66734063HCID 66734063, compound

Product 1

HCID 66734138HCID 66734138, compound

Procedure

According to the general procedure (GP10), microwave-assisted Pictet-Spengler reaction (60 W; 140° C.; 6.5 bars; 10 min.) between 2-(2-ethyl-4-iodo-imidazol-1-yl)-ethylamine (3.880 mmol) and (4-trifluoromethyl-phenoxy)-acetaldehyde (0.792 g; 3.880 mmol) afforded 3-ethyl-1-iodo-8-(4-trifluoromethyl-phenoxymethyl)-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine. LC-MS: tR=0.73 min.; [M+H]+=452.12 g/mol.

Sources & evidence

ORD record
ord-68843c04000d4ef5b96c544b8f27cbc1
Source dataset
uspto-grants-2012_05
Patent number
US08188082B2

Reaction notes

Loading…