3-(p-Methylphenyl)propanal → 1,3-Dimethyl-8-(2-p-tolylethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine

HRID 1929675Notes

Reaction equation

HRID 1929675 reaction equation
[CH3:1][C:2]1[N:3]([CH2:8][CH2:9][NH2:10])[CH:4]=[C:5]([CH3:7])[N:6]=1.[C:11]1([CH3:21])[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][CH:19]=O)=[CH:13][CH:12]=1>>[CH3:7][C:5]1[N:6]=[C:2]([CH3:1])[N:3]2[CH2:8][CH2:9][NH:10][CH:19]([CH2:18][CH2:17][C:14]3[CH:15]=[CH:16][C:11]([CH3:21])=[CH:12][CH:13]=3)[C:4]=12

Participants

3

Reactant 2

HCID 648123-(p-Methylphenyl)propanalHCID 184607002-(2,4-Dimethyl-1H-imidazol-1-yl)ethanamine

Product 1

HCID 667338011,3-Dimethyl-8-(2-p-tolylethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine

Procedure

Prepared according to the previously described general procedure (GP11) by reaction of 2-(2,4-dimethyl-imidazol-1-yl)-ethylamine with 3-p-tolyl-propionaldehyde. LC-MS: tR=0.57 min.; [M+H]+=270 g/mol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-b3e1dee8599e4cc4a5e22fb66fbb8bb8
Source dataset
uspto-grants-2012_05
Patent number
US08188082B2

Reaction notes

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