2-(2,4-Dimethyl-1H-imidazol-1-yl)ethanamine → 8-[2-(2,4-Dichlorophenyl)ethyl]-1,3-dimethyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine

HRID 1929681Notes

Reaction equation

HRID 1929681 reaction equation
[CH3:1][C:2]1[N:3]([CH2:8][CH2:9][NH2:10])[CH:4]=[C:5]([CH3:7])[N:6]=1.[Cl:11][C:12]1[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:13]=1[CH2:19][CH2:20][CH:21]=O>>[Cl:11][C:12]1[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:13]=1[CH2:19][CH2:20][CH:21]1[NH:10][CH2:9][CH2:8][N:3]2[C:2]([CH3:1])=[N:6][C:5]([CH3:7])=[C:4]12

Participants

3

Reactant 2

HCID 184607002-(2,4-Dimethyl-1H-imidazol-1-yl)ethanamineHCID 218597273-(2,4-Dichlorophenyl)propanal

Product 1

HCID 667337868-[2-(2,4-Dichlorophenyl)ethyl]-1,3-dimethyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine

Procedure

Prepared according to the previously described general procedure (GP11) by reaction of 2-(2,4-dimethyl-imidazol-1-yl)-ethylamine with 3-(2,4-dichloro-phenyl)-propionaldehyde. LC-MS: tR=0.64 min.; [M+H]+=324 g/mol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-09a3b0ae7f414f449cf580f889ecaa33
Source dataset
uspto-grants-2012_05
Patent number
US08188082B2

Reaction notes

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