Dichloromethane methanol → HCID 66733966, compound

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Reaction Steps

According to the general procedure (GP12), chlorination of 3-ethyl-1-iodo-8-(3-trifluoromethyl-phenoxymethyl)-5,6-dihydro-8H-imidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester (1.272 g; 2.307 mmol), and purification by FC (DCM/MeOH=60/1) gave the expected product 1-chloro-3-ethyl-8-(3-trifluoromethyl-phenoxymethyl)-5,6-dihydro-8H-imidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester as a yellow oil (0.403 g; 38%). LC-MS: tR=1.03 min.; [M+H]+=460.37 g/mol.

Provenance & Evidence