Tetrahydrofuran → HCID 66734230, compound

Participants

Reaction Steps

According to the previously described general procedure (GP12C), treatment of 8-[2-(3-chloro-4-trifluoromethyl-phenyl)-ethyl]-3-ethyl-1-iodo-5,6-dihydro-8H-imidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester (2.070 g; 3.546 mmol) with 1M ethylmagnesium bromide in THF (15.6 ml; 15.6 mmol; 4.4 eq.) afforded 8-[2-(3-chloro-4-trifluoromethyl-phenyl)-ethyl]-3-ethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester (1.170 g; 72%) as a pale yellow oil. LC-MS: tR=0.95 min.; [M+H]+=457.98 g/mol.

Provenance & Evidence