Water → HCID 16722330, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the compound obtained in Example 33 (100 mg) in tetrahydrofuran/methanol (3 mL/3 mL) was added sodium methoxide (102 mg) and the mixture was stirred at 50° C. overnight. After cooling to room temperature, to the reaction mixture was added water and ethyl acetate and the mixture was stirred. The organic layer was dried over magnesium sulfate and filtered. The filtrate was concentrated in vacuo and the resultant crude product was purified by a column chromatography on silica gel (solvent; hexane/ethyl acetate=80/20 to 60/40) to give 6-(2-chlorophenyl)-7-(4-chlorophenyl)-3-(N-cyclopentylcarbamoyl)-2-methoxypyrazol o[1,5-a]pyrimidine (57.2 mg; yield: 63%) as a pale yellow powder.

Provenance & Evidence