Water → HCID 68921803, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the compound obtained in Example 36 (24 mg) in methanol/tetrahydrofuran (2 mL/1 mL) was added sodium methoxide (23 mg) and the mixture was stirred at 100° C. for 2 hours in a microwave reactor. After cooling to room temperature, to the reaction mixture was added chloroform and water and the organic layer was separated and concentrated in vacuo and the resultant crude product was purified by a column chromatography on NH-silica gel (Chromatorex NH-silica gel/Fuji Silicia Chem., solvent; hexane/ethyl acetate=65/35 to 30/70) to give 6-(2-chlorophenyl)-7-(4-chlorophenyl)-3-(N-cyclopentylcarbamoyl)-2,5-dimethoxypyrazolo[1,5-a]pyrimidine (17.8 mg; yield: 81%) as a colorless solid.

Provenance & Evidence