Sodium Iodide → HCID 68917663, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the compound obtained in Example 40 (60 mg) in water/acetonitrile (0.3 mL/2.4 mL) was added 1,4-dichlorobutane (81.6 mg), potassium carbonate (88.8 mg) and sodium iodide (6.8 mg) and the mixture was stirred at 150° C. for 3 hours in a microwave reactor. After cooling to room temperature, to the reaction mixture was added ethyl acetate and water and the mixture was stirred. The organic layer was extracted and dried over magnesium sulfate and filtered. The filtrate was concentrated in vacuo and the resultant crude product was purified by a column chromatography on silica gel (solvent; hexane/ethyl acetate=90/10 to 70/30) to give 6-(2-chlorophenyl)-7-(4-chlorophenyl)-3-(N-cyclopentylcarbamoyl)-2-(1-pyrrolidinyl)-pyrazolo[1,5-a]pyrimidine (25 mg; yield: 37%) as a yellow solid.

Provenance & Evidence