HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dichlorobutane → 6-(2-Chlorophenyl)-7-(4-trifluoromethylphenyl)-3-ethoxycarbonyl-2-(pyrrolidin-1-yl)pyrazolo[1,5-a]-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dichlorobutane | HCID 8059 | — |
| Reactant | 6-(2-Chlorophenyl)-7-(4-trifluoromethylphenyl)-3-ethoxycarbonyl-2-aminopyrazolo-[1,5-a]pyrimidine | HCID 67272132 | — |
| Product | 6-(2-Chlorophenyl)-7-(4-trifluoromethylphenyl)-3-ethoxycarbonyl-2-(pyrrolidin-1-yl)pyrazolo[1,5-a]-pyrimidine | HCID 67272789 | 26% |
Reaction Steps
The compound obtained in Example 484 (2.1 g) and 1,4-dichlorobutane (2.9 g) were treated in the same manner as described in Example 43 to give 6-(2-chlorophenyl)-7-(4-trifluoromethylphenyl)-3-ethoxycarbonyl-2-(pyrrolidin-1-yl)pyrazolo[1,5-a]-pyrimidine (0.61 g, yield: 26%) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188097B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-79c1f076166b4bedadff9895e6a9afcf |
| Source note | uspto-grants-2012_05 |