Water → HCID 54490493, compound

Participants

Reaction Steps

To a solution of the mixture of the compound 2a and 2b (27.6 g) in methylene chloride (200 mL) was added dropwise oxalyl chloride (31.6 mL) and a few drops of pyridine and the mixture was refluxed under heating for 4 hours. The reaction mixture was poured to water gradually and the mixture was extracted with methylene chloride. The organic layer was dried over magnesium sulfate and filtered. The filtrate was concentrated in vacuo to give methyl 2-cyano-3-chloro-4,4,4-trifluoro-2-butenoate as a crude product.

Provenance & Evidence