(3R)-1-benzylpyrrolidin-3-amine → {4-[3-((R)-1-Benzyl-pyrrolidin-3-yl)-ureido]-cyclohexyl}-carbamic acid tert-butyl ester

Participants

Reaction Steps

A solution of (4-tert-butoxycarbonylamino-cyclohexyl)-carbamic acid phenyl ester (1 eq.) and (R)-1-benzyl-pyrrolidin-3-ylamine (1 eq.) in MeOH is heated using microwave radiation at 100° C. for 30 minutes. The resulting solution is purified by reverse phase column chromatography (Isolute™ C18, 0-100% acetonitrile in water 0.1% HCl) to afford the title compound.

Provenance & Evidence