2,4-Dichloro-1,3,5-triazine → HCID 68442457, compound

Participants

Reaction Conditions

Reaction Steps

(R)-3-Amino-pyrrolidine-1-carboxylic acid allyl ester (1 eq.) is dissolved in DCM. The reaction mixture is cooled to 0° C. and a solution of 2,4-dichloro-[1,3,5]triazine (1 eq.) in DCM is added dropwise. The reaction mixture is stirred at room temperature for 2 hours. The reaction mixture is re-cooled to 0° C. and a solution of (4-amino-cyclohexyl)-carbamic acid tert-butyl ester (1 eq.) in DCM is added dropwise. The reaction mixture is stirred at room temperature overnight. The reaction mixture is partitioned between (0.2 M) HCl(aq) and DCM. The organics are washed with water, saturated NaHCO3(aq) and brine. The combined organics are dried (MgSO4), filtered and reduced in vacuo, to yield the title compound.

Provenance & Evidence