HCID 24755621, compound → HCID 25059377, compound

Participants

Reaction Steps

N-{(1S,2R,3S,4R)-4-[2-{(R)-3-[2-Chloro-9-((1R,2S,3R,4S)-2,3-dihydroxy-4-propionylamino-cyclopentyl)-9H-purin-6-ylamino]-pyrrolidin-1-yl}-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide (1 eq.) and 1-pyridin-3-yl-3-(R)-pyrrolidin-3-yl-urea (3 eq.) are dissolved in EtOH. The reaction mixture is refluxed at room temperature for 48 hours. The reaction mixture is reduced in vacuo and purified by reverse phase column chromatography (Isolute™ C18, 0-100% acetonitrile in water-0.1% TFA) to yield the title compound.

Provenance & Evidence