4,5-Dimethoxyanthranilic acid → 6,7-Dimethoxy-3H-quinazolin-4-one

Participants

Reaction Conditions

Reaction Steps

36.9 g of 4,5-dimethoxyanthranilic acid was mixed with 25.0 g of formamidine hydrochloride, and the mixture was stirred at 210° C. for 30 minutes. After completion of the reaction, the solid thus obtained was cooled to room temperature, stirred with 200 ml (0.33 M) of aqueous sodium hydroxide and filtered under a reduced pressure. The solid thus obtained was washed with water and air-dried to obtain the title compound (24.6 g, 64%).

Provenance & Evidence