HCID 136388729, compound → HCID 136388728, compound

Participants

Reaction Steps

100 mg of the compound obtained in step 1) was diluted with 2 ml of methylene chloride, and 0.2 ml of trifluoroacetic acid was added thereto. The resulting mixture was stirred at room temperature for one hour. After the reaction terminated, the resulting solution was distilled under a reduced pressure to remove a solvent. The resulting residue was alkalinized with a saturated sodium bicarbonate and extracted with a mixed solvent of chloroform and 2-propanol (3:1). The organic layer was dried over anhydrous sodium sulfate, filtered and distilled under a reduced pressure. The resulting residue was purified by column chromatography (methylene chloride:methanol=10:1) to obtain the title compound (69 mg, 87%).

Provenance & Evidence