HCID 68750156, compound → HCID 135897740, compound

HRID 1929791Notes

Reaction equation

HRID 1929791 reaction equation
[NH:1]1[CH2:4][CH:3]([O:5][C:6]2[CH:7]=[C:8]3[C:13](=[CH:14][C:15]=2[OH:16])[N:12]=[CH:11][N:10]=[C:9]3[NH:17][C:18]2[CH:23]=[CH:22][C:21]([F:24])=[C:20]([Cl:25])[C:19]=2[F:26])[CH2:2]1.ClC1C(F)=C(NC2C3C(=[CH:41][C:42](OC)=[C:43]([O:46][C@H]4CCNC4)C=3)N=CN=2)C=C(F)C=1>>[Cl:25][C:20]1[C:19]([F:26])=[C:18]([NH:17][C:9]2[C:8]3[C:13](=[CH:14][C:15]([OH:16])=[C:6]([O:5][CH:3]4[CH2:4][N:1]([C:43](=[O:46])[CH:42]=[CH2:41])[CH2:2]4)[CH:7]=3)[N:12]=[CH:11][N:10]=2)[CH:23]=[CH:22][C:21]=1[F:24]

Participants

3

Reactant 2

HCID 68750156HCID 68750156, compoundHCID 136388728HCID 136388728, compound

Product 1

HCID 135897740HCID 135897740, compoundYield 25%

Procedure

The procedure of step 7) of Example 1 was repeated except for using the compound obtained in step 2) instead of N-(3-chloro-2,5-difluorophenyl)-7-methoxy-6-((3S)-pyrrolidin-3-yloxy)quinazolin-4-amine to obtain the title compound (20 mg, 25%).

Sources & evidence

ORD record
ord-ef85dc34db044593a85eba8a26ad6ce4
Source dataset
uspto-grants-2012_05
Patent number
US08188102B2

Reaction notes

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