HCID 86643311, compound → HCID 68625340, compound

HRID 1929792Notes

Reaction equation

HRID 1929792 reaction equation
[Cl:1][C:2]1[C:3]([F:36])=[C:4]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][C:16](CCOC)=[C:17]([O:20][CH:21]4[CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22]4)[CH:18]=3)[N:13]=[CH:12][N:11]=2)[CH:5]=[CH:6][C:7]=1[F:8].ClC1C(F)=C(NC2C3C(=C[C:52]([OH:68])=[C:53]([O:56][CH:57]4CN(C(OC(C)(C)C)=O)C4)C=3)N=CN=2)C=CC=1F>>[NH:23]1[CH2:24][CH:21]([O:20][C:17]2[CH:18]=[C:19]3[C:14](=[CH:15][C:16]=2[O:68][CH2:52][CH2:53][O:56][CH3:57])[N:13]=[CH:12][N:11]=[C:10]3[NH:9][C:4]2[CH:5]=[CH:6][C:7]([F:8])=[C:2]([Cl:1])[C:3]=2[F:36])[CH2:22]1

Participants

3

Reactant 2

HCID 86643311HCID 86643311, compoundHCID 136381041HCID 136381041, compound

Product 1

HCID 68625340HCID 68625340, compoundYield 100%

Procedure

The procedure of step 2) of Example 115 was repeated except for using the compound obtained in step 1) instead of tert-butyl 3-(4-(3-chloro-2,4-difluorophenylamino)-7-hydroxyquinazolin-6-yloxy)azetidin-1-carboxylate to obtain the title compound (37 mg, 100%).

Sources & evidence

ORD record
ord-a822d6853d284e1a9b0aff5b94975714
Source dataset
uspto-grants-2012_05
Patent number
US08188102B2

Reaction notes

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