HCID 68625340, compound → HCID 25125760, compound

HRID 1929793Notes

Reaction equation

HRID 1929793 reaction equation
[NH:1]1[CH2:4][CH:3]([O:5][C:6]2[CH:7]=[C:8]3[C:13](=[CH:14][C:15]=2[O:16][CH2:17][CH2:18][O:19][CH3:20])[N:12]=[CH:11][N:10]=[C:9]3[NH:21][C:22]2[CH:27]=[CH:26][C:25]([F:28])=[C:24]([Cl:29])[C:23]=2[F:30])[CH2:2]1.N1CC([O:35][C:36]2C=C3C(=[CH:44][C:45]=2O)N=CN=C3NC2C=CC(F)=C(Cl)C=2F)C1>>[Cl:29][C:24]1[C:23]([F:30])=[C:22]([NH:21][C:9]2[C:8]3[C:13](=[CH:14][C:15]([O:16][CH2:17][CH2:18][O:19][CH3:20])=[C:6]([O:5][CH:3]4[CH2:2][N:1]([C:36](=[O:35])[CH:45]=[CH2:44])[CH2:4]4)[CH:7]=3)[N:12]=[CH:11][N:10]=2)[CH:27]=[CH:26][C:25]=1[F:28]

Participants

3

Reactant 2

HCID 68625340HCID 68625340, compoundHCID 136388728HCID 136388728, compound

Product 1

HCID 25125760HCID 25125760, compoundYield 50%

Procedure

The procedure of step 3) of Example 115 was repeated except for using the compound obtained in step 2) instead of 6-(azetidin-3-yloxy)-4-(3-chloro-2,4-difluorophenylamino)quinazolin-7-ol to obtain the title compound (21 mg, 50%).

Sources & evidence

ORD record
ord-1d1626dca2a14d05a41a5a9f04e6e0f3
Source dataset
uspto-grants-2012_05
Patent number
US08188102B2

Reaction notes

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