HCID 68747678, compound → HCID 68748396, compound

HRID 1929794Notes

Reaction equation

HRID 1929794 reaction equation
[C:1]([C@@H:4]1[CH2:9][C@@H:8]([O:10][C:11]2[CH:12]=[C:13]3[C:18](=[CH:19][C:20]=2[O:21][CH3:22])[N:17]=[CH:16][N:15]=[C:14]3[NH:23][C:24]2[CH:29]=[CH:28][C:27]([F:30])=[C:26]([Cl:31])[C:25]=2[F:32])[CH2:7][CH2:6][N:5]1C(OC(C)(C)C)=O)(=[O:3])[NH2:2].ClC1C(F)=C(NC2C3C(=CC(O)=C(OC4CN(C(OCCCC)=O)C4)C=3)N=CN=2)C=CC=1F>>[Cl:31][C:26]1[C:25]([F:32])=[C:24]([NH:23][C:14]2[C:13]3[C:18](=[CH:19][C:20]([O:21][CH3:22])=[C:11]([O:10][C@H:8]4[CH2:7][CH2:6][NH:5][C@H:4]([C:1]([NH2:2])=[O:3])[CH2:9]4)[CH:12]=3)[N:17]=[CH:16][N:15]=2)[CH:29]=[CH:28][C:27]=1[F:30]

Participants

3

Reactant 2

HCID 68747678HCID 68747678, compoundHCID 136388729HCID 136388729, compound

Product 1

HCID 68748396HCID 68748396, compoundYield 71%

Procedure

The procedure of step 2) of Example 115 was repeated except for using the compound obtained in step 3) instead of tent-butyl 3-(4-(3-chloro-2,4-difluorophenylamino)-7-hydroxyquinazolin-6-yloxy)azetidin-1-carboxylate to obtain the title compound (580 mg, 71%).

Sources & evidence

ORD record
ord-6b5d01df565a486bb7f392ed872457c2
Source dataset
uspto-grants-2012_05
Patent number
US08188102B2

Reaction notes

Loading…