HCID 68623841, compound → HCID 25126089, compound

HRID 1929795Notes

Reaction equation

HRID 1929795 reaction equation
[Cl:1][C:2]1[C:3]([F:32])=[C:4]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][C:16]([O:30][CH3:31])=[C:17]([O:20][C@H:21]4[CH2:26][CH2:25][NH:24][C@H:23]([C:27]([NH2:29])=[O:28])[CH2:22]4)[CH:18]=3)[N:13]=[CH:12][N:11]=2)[CH:5]=[CH:6][C:7]=1[F:8].ClC1C(F)=C(NC2C3C(=[CH:47][C:48](OC)=[C:49]([O:52][C@H]4CCNC4)C=3)N=CN=2)C=CC=1F>>[C:49]([N:24]1[CH2:25][CH2:26][C@H:21]([O:20][C:17]2[CH:18]=[C:19]3[C:14](=[CH:15][C:16]=2[O:30][CH3:31])[N:13]=[CH:12][N:11]=[C:10]3[NH:9][C:4]2[CH:5]=[CH:6][C:7]([F:8])=[C:2]([Cl:1])[C:3]=2[F:32])[CH2:22][C@H:23]1[C:27]([NH2:29])=[O:28])(=[O:52])[CH:48]=[CH2:47]

Participants

3

Reactant 2

HCID 68623841HCID 68623841, compoundHCID 68748396HCID 68748396, compound

Product 1

HCID 25126089HCID 25126089, compoundYield 69%

Procedure

The procedure of step (1-7) was repeated except for using the compound obtained in step 4) instead of N-(3-chloro-2,4-difluorophenyl)-7-methoxy-6-((3S)-pyrrolidin-3-yloxy)quinazolin-4-amine to obtain the title compound (10 mg, 69%).

Sources & evidence

ORD record
ord-a5296cc548ba45a589c4d66d5f79272e
Source dataset
uspto-grants-2012_05
Patent number
US08188102B2

Reaction notes

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