(1R,2R)-2-Aminocyclohexanol → HCID 11951302, compound

HRID 1929803Notes

Reaction equation

HRID 1929803 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([O:17][CH2:18][CH2:19][O:20][CH3:21])=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[NH2:22][C@@H:23]1[CH2:28][CH2:27][CH2:26][CH2:25][C@H:24]1[OH:29]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9]([O:17][CH2:18][CH2:19][O:20][CH3:21])=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([NH:22][C@@H:23]2[CH2:28][CH2:27][CH2:26][CH2:25][C@H:24]2[OH:29])=[O:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 735777(1R,2R)-2-AminocyclohexanolHCID 67504961HCID 67504961, compound

Product 1

HCID 11951302HCID 11951302, compound

Procedure

The title compound was synthesized in analogy to Example 5d, using 5-(4-chloro-phenyl)-6-(2-methoxy-ethoxy)-nicotinic acid and (1R,2R)-2-amino-cyclohexanol as starting materials, MS (ISP) 405.2, 407.2 (M+H)+.

Sources & evidence

ORD record
ord-59a6ea992c3a4732ad45a80a1a9afe55
Source dataset
uspto-grants-2012_05
Patent number
US08188093B2

Reaction notes

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