HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-Fluorophenyl)-6-cyclopropylmethoxy-nicotinic acid → N-((R)-2-Cyclopropyl-2-hydroxy-propyl)-6-cyclopropylmethoxy-5-(4-fluoro-phenyl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-Fluorophenyl)-6-cyclopropylmethoxy-nicotinic acid | HCID 21109721 | — |
| Reactant | (2R)-1-amino-2-cyclopropyl-propan-2-ol | HCID 51684102 | — |
| Product | N-((R)-2-Cyclopropyl-2-hydroxy-propyl)-6-cyclopropylmethoxy-5-(4-fluoro-phenyl)-nicotinamide | HCID 11950408 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 5d, using 5-(4-fluorophenyl)-6-cyclopropylmethoxy-nicotinic acid and (R)-α-(aminomethyl)-α-methyl-cyclopropanemethanol as starting materials, MS (ISP) 385.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188093B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-dd765dd3c4d94787ad6447572d8de575 |
| Source note | uspto-grants-2012_05 |