HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyethanol → 5-(4-Chloro-phenyl)-N-(2-cyclopropyl-2-hydroxy-propyl)-6-(2-methoxy-ethoxy)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyethanol | HCID 8019 | — |
| Reactant | 4-Chlorophenylboronic acid | HCID 74299 | — |
| Reactant | Methyl 5-bromo-6-hydroxynicotinate | HCID 2764315 | — |
| Reactant | 1-Amino-2-cyclopropylpropan-2-ol | HCID 21109692 | — |
| Product | 5-(4-Chloro-phenyl)-N-(2-cyclopropyl-2-hydroxy-propyl)-6-(2-methoxy-ethoxy)-nicotinamide | HCID 11951301 | — |
Reaction Steps
The title compound was synthesized in analogy to the procedure described for the preparation of Example 6, using 5-bromo-1,6-dihydro-6-oxo-3-pyridinecarboxylic acid methyl ester, 2-methoxy-ethanol (commercially available), 4-chlorophenyl-boronic acid (commercially available) and rac-1-amino-2-cyclopropyl-propan-2-ol (commercially available) as starting materials. MS (ISP): 405.4 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188093B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-79dd6f9a64b247d0af026537a7587ebc |
| Source note | uspto-grants-2012_05 |