HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyethanol → 5-(4-Chloro-phenyl)-N-((R)-1-hydroxymethyl-pentyl)-6-(2-methoxy-ethoxy)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyethanol | HCID 8019 | — |
| Reactant | 4-Chlorophenylboronic acid | HCID 74299 | — |
| Reactant | Methyl 5-bromo-6-hydroxynicotinate | HCID 2764315 | — |
| Reactant | (R)-2-Aminohexan-1-ol | HCID 6994402 | — |
| Product | 5-(4-Chloro-phenyl)-N-((R)-1-hydroxymethyl-pentyl)-6-(2-methoxy-ethoxy)-nicotinamide | HCID 24856590 | — |
Reaction Steps
The title compound was synthesized in analogy to the procedure described for the preparation of Example 6, using 5-bromo-1,6-dihydro-6-oxo-3-pyridinecarboxylic acid methyl ester, 2-methoxy-ethanol (commercially available), 4-chlorophenyl-boronic acid (commercially available) and (R)-(−)-2-amino-1-hexanol (commercially available) as starting materials. MS (ISP): 407.4 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188093B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-1f5dee25f3904980ac61bd870bda8b06 |
| Source note | uspto-grants-2012_05 |