HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Cyanophenylboronic acid → 5-(4-Cyano-phenyl)-6-cyclopropylmethoxy-N-((trans)-2-hydroxy-cyclohexyl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Cyanophenylboronic acid | HCID 2734326 | — |
| Reactant | 5-bromo-6-cyclopropylmethoxy-N-(trans-2-hydroxy-cyclohexyl)-nicotinamide | HCID 67504971 | — |
| Product | 5-(4-Cyano-phenyl)-6-cyclopropylmethoxy-N-((trans)-2-hydroxy-cyclohexyl)-nicotinamide | HCID 24856637 | — |
Reaction Steps
The title compound was synthesized in analogy to the procedure described for the preparation of Example 31, using 5-bromo-6-cyclopropylmethoxy-N-(trans-2-hydroxy-cyclohexyl)-nicotinamide and 4-cyanophenylboronic acid (commercially available) as starting materials. MS (ISP): 392.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188093B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-a8dfe5e0479f4eee89bc97e784b2335a |
| Source note | uspto-grants-2012_05 |