N-Methylpropylamine → HCID 24856756, compound

HRID 1929870Notes

Reaction equation

HRID 1929870 reaction equation
CO[C:3](=[O:12])[C:4]1[CH:9]=[C:8](Br)[C:7](Cl)=[N:6][CH:5]=1.[CH3:13][NH:14][CH2:15][CH2:16][CH3:17].[Cl:18][C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1.[NH2:28][CH2:29][C:30]([CH:33]1[CH2:35][CH2:34]1)([OH:32])[CH3:31]>>[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C:8]2[C:7]([N:14]([CH3:13])[CH2:15][CH2:16][CH3:17])=[N:6][CH:5]=[C:4]([CH:9]=2)[C:3]([NH:28][CH2:29][C:30]([CH:33]2[CH2:35][CH2:34]2)([OH:32])[CH3:31])=[O:12])=[CH:21][CH:20]=1

Participants

5

Reactant 4

HCID 12315N-MethylpropylamineHCID 742994-Chlorophenylboronic acidHCID 2764313Methyl 5-bromo-6-chloronicotinateHCID 211096921-Amino-2-cyclopropylpropan-2-ol

Product 1

HCID 24856756HCID 24856756, compound

Procedure

The title compound was synthesized in analogy to the procedure described for the preparation of Example 43, using 5-bromo-6-chloro-nicotinic acid methyl ester, N-methyl-N-propylamine, (4-chloro-phenyl)-boronic acid and rac-1-amino-2-cyclopropyl-propan-2-ol as starting materials. MS (ISP): 402.5 (M+H+).

Workup

  1. customdescribed for the preparation of Example 43

Sources & evidence

ORD record
ord-0f63461dfdfa417ebeb01e9ab7c0a94f
Source dataset
uspto-grants-2012_05
Patent number
US08188093B2

Reaction notes

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