HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanemethanol → 6-cyclopropylmethoxy-5-(4-fluoro-phenyl)-N-(2-hydroxy-2-methyl-propyl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanemethanol | HCID 75644 | — |
| Reactant | 5-Bromo-6-chloropyridine-3-carboxylic acid | HCID 285433 | — |
| Reactant | 4-Fluorophenylboronic acid | HCID 285645 | — |
| Reactant | 1-Amino-2-methyl-propan-2-ol hydrochloride | HCID 12386181 | — |
| Product | 6-cyclopropylmethoxy-5-(4-fluoro-phenyl)-N-(2-hydroxy-2-methyl-propyl)-nicotinamide | HCID 21109656 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 31, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, hydroxymethyl-cyclopropan, 4-fluorophenylboronic acid and 1-amino-2-methyl-propan-2-ol hydrochloride as starting materials to yield 6-cyclopropylmethoxy-5-(4-fluoro-phenyl)-N-(2-hydroxy-2-methyl-propyl)-nicotinamide. MS (ISP) 359.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188093B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-8106fa7008274793a807ffed1335f1ae |
| Source note | uspto-grants-2012_05 |