(1R,2R)-2-Aminocyclohexanol → HCID 67505090, compound

HRID 1929896Notes

Reaction equation

HRID 1929896 reaction equation
[Br:1][C:2]1[C:3]([O:12][CH2:13][CH:14]2[CH2:16][CH2:15]2)=[N:4][C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[NH2:17][C@@H:18]1[CH2:23][CH2:22][CH2:21][CH2:20][C@H:19]1[OH:24]>>[Br:1][C:2]1[C:3]([O:12][CH2:13][CH:14]2[CH2:16][CH2:15]2)=[N:4][C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7]([NH:17][C@@H:18]1[CH2:23][CH2:22][CH2:21][CH2:20][C@H:19]1[OH:24])=[O:9]

Participants

3

Reactant 2

HCID 735777(1R,2R)-2-AminocyclohexanolHCID 67505369HCID 67505369, compound

Product 1

HCID 67505090HCID 67505090, compound

Procedure

The title compound was synthesized in analogy to the procedure described for the preparation of Example 31b, using 5-bromo-6-cyclopropylmethoxy-2-methyl-nicotinic acid and (1R,2R)-2-amino-1-cyclohexanol as starting materials, MS (ISP): 383.1, 385.1 (M+H)+.

Workup

  1. customdescribed for the preparation of Example 31b

Sources & evidence

ORD record
ord-d73842cd4e514592bdb558711e4d1ad6
Source dataset
uspto-grants-2012_05
Patent number
US08188093B2

Reaction notes

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