(1R,2R)-2-Aminocyclohexanol → HCID 42629035, compound

HRID 1929914Notes

Reaction equation

HRID 1929914 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([O:21][CH2:22][CH:23]3[CH2:25][CH2:24]3)=[N:10][C:11]([C:17]([F:20])([F:19])[F:18])=[C:12]([CH:16]=2)[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[NH2:26][C@@H:27]1[CH2:32][CH2:31][CH2:30][CH2:29][C@H:28]1[OH:33]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([O:21][CH2:22][CH:23]3[CH2:25][CH2:24]3)=[N:10][C:11]([C:17]([F:20])([F:19])[F:18])=[C:12]([CH:16]=2)[C:13]([NH:26][C@@H:27]2[CH2:32][CH2:31][CH2:30][CH2:29][C@H:28]2[OH:33])=[O:15])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 735777(1R,2R)-2-AminocyclohexanolHCID 67505272HCID 67505272, compound

Product 1

HCID 42629035HCID 42629035, compound

Procedure

The title compound was synthesized in analogy to Example 5d, using 5-(4-Chloro-phenyl)-6-cyclopropylmethoxy-2-trifluoromethyl-nicotinic acid and (1R,2R)-2-amino-1-cyclohexanol as starting materials, MS (ISP) 469.3 (M+H)+.

Sources & evidence

ORD record
ord-5250e3bef7e5433181f7e7ed40276b3b
Source dataset
uspto-grants-2012_05
Patent number
US08188093B2

Reaction notes

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