HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1R,2R)-2-Aminocyclohexanol → N-((1R,2R)-2-Hydroxy-cyclohexyl)-6-[2-(3-methyl-3H-imidazol-4-yl)-ethyl]-5-(4-trifluoromethyl-phenyl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1R,2R)-2-Aminocyclohexanol | HCID 735777 | — |
| Reactant | 5-Ethynyl-1-methyl-1H-imidazole | HCID 3333106 | — |
| Reactant | 6-Chloro-5-(4-trifluoromethyl-phenyl)-nicotinic acid methyl ester | HCID 86619575 | — |
| Product | N-((1R,2R)-2-Hydroxy-cyclohexyl)-6-[2-(3-methyl-3H-imidazol-4-yl)-ethyl]-5-(4-trifluoromethyl-phenyl)-nicotinamide | HCID 24857346 | — |
Reaction Steps
The title compound was synthesized in analogy to the procedure described for the preparation of Example 140, using 5-ethynyl-1-methyl-1H-imidazole (CAN 71759-92-7), 6-chloro-5-(4-trifluoromethyl-phenyl)-nicotinic acid methyl ester, and (1R,2R)-2-amino-cyclohexanol (commercially available) as starting materials, LC at 215 nm; Rt 3.11: 100%, m/z (ES+): 473.5 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188093B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-2374145f33d74dd19def9930eeb1645e |
| Source note | uspto-grants-2012_05 |