HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1R,2R)-2-Aminocyclohexanol → 6-[2-(5-Fluoro-pyridin-2-yl)-ethyl]-N-((1R,2R)-2-hydroxy-cyclohexyl)-5-(4-trifluoromethyl-phenyl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1R,2R)-2-Aminocyclohexanol | HCID 735777 | — |
| Reactant | 2-Ethynyl-5-fluoropyridine | HCID 44754926 | — |
| Reactant | 6-Chloro-5-(4-trifluoromethyl-phenyl)-nicotinic acid methyl ester | HCID 86619575 | — |
| Product | 6-[2-(5-Fluoro-pyridin-2-yl)-ethyl]-N-((1R,2R)-2-hydroxy-cyclohexyl)-5-(4-trifluoromethyl-phenyl)-nicotinamide | HCID 24797619 | — |
Reaction Steps
The title compound was synthesized in analogy to the procedure described for the preparation of Example 140, using 2-ethynyl-5-fluoro-pyridine (CAN 884494-34-2), 6-chloro-5-(4-trifluoromethyl-phenyl)-nicotinic acid methyl ester, and (1R,2R)-2-amino-cyclohexanol (commercially available) as starting materials, LC at 215 nm; Rt 4.26: 95%, m/z (ES+): 488.5 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188093B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-c40b067ec86a415b9717b44e629f9a2c |
| Source note | uspto-grants-2012_05 |